All paths lead to NEMO – Journal of Clinical Investigation

The transcription factor NF-κB is found in all cell types and is involved in cellular responses to stimuli as varied as stress, cancer, and viral infection. In the current issue, four papers highlight the importance of NF-κB as a central regulator, showing its importance in skeletal muscle strength, colitis-associated tumorigenesis, central tolerance, and endothelial cell function.