I contacted Dr. Alain Fischer once, read message here. And his response here. FDA Halts Gene Therapy Experiments; By Rick Weiss, Washington Post Staff Writer, Thursday, March 3, 2005; 2:20 PM The Food and Drug Administration has suspended several U.S. gene therapy experiments after learning that a third child who underwent treatment in France has…
NEMO Gene
Dr. Ashish Jain publishes article about NEMO with Dr. Jordan Orange
Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation. Jain, A., Ma, C. A., Lopez-Granados, E., Means, G., Brady, W., Orange, J. S., Liu, S., Holland, S., Derry, J. M.J. J. Clin. Invest. 2004 114: p. 1593-1602 Read the article here.
Dr. Jordan Orange publishes article about NEMO PI without ectodermal dysplasia.
On the Journal of Clinical Allergy and Immunology: Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia.
Gene therapy article @ BBC
Safer route to gene therapy found Scientists say they have found a safer way of controlling genes to treat disease. Current methods of switching genes on and off usually involve complicated systems and have serious side effects like cancer. Scientists at the Children’s Hospital in Boston say their new system should help overcome some of…
Insurers and genetic tests
What if my insurer knew that I have a gene that predisposes me to diabetes? Will they cover me? Theres a very interesting article today from switzerland: “Insurers are to be granted access to genetic tests, but only in cases involving large life insurance policies. Parliament approved the measure on Wednesday as part of a…
Articles citing Dr. Orange
The Journal of Clinical Investigation found today 2 articles citing Dr. Orange research on NEMO. Dr. Orange’s article is “Deficient natural killer cell cytotoxicity in patients with IKK-{gamma}/NEMO mutations” published in 2002. And the articles are: Combined deficiency in I{kappa}B{alpha} and I{kappa}B{epsilon} reveals a critical window of NF-{kappa}B activity in natural killer cell differentiation Samson,…
Dr. Jordan Orange publishes presentation of NEMO
On the Journal of Clinical Allergy and Immunology: The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation. Orange JS, Jain A, Ballas ZK, Schneider LC, Geha RS, Bonilla FA. Department of Immunology, Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. BACKGROUND: An increasing number of rare genetic defects…
Andres @ Harvard Medical School
I participated today @ the HST 180. HST stands for Health Sciences and Technology, a joint program between Harvard Medical School and MIT for both graduate and medical students. The topics discussed in the class cover a broad spectrum of medical conditions in which the underlying genetic causes are known. The genetics for each disorder…
Commentary from Dr. Jordan Orange & Dr. Raif S. Geha
Finding NEMO: genetic disorders of NFkB activation Jordan S. Orange and Raif S. Geha Division of Immunology, Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA Comentary about NEMO from Dr. Jordan Orange, Dr. Raif S. Geha. Read the Commentary here. ATF
Jordan Orange article about NEMO
Deficient natural killer cell cytotoxicity in patients with IKK-γ/NEMO mutations Jordan S. Orange, Scott R. Brodeur, Ashish Jain, Francisco A. Bonilla, Lynda C. Schneider, Roberto Kretschmer, Samuel Nurko, Wendy L. Rasmussen, Julia R. Köhler, Stephen E. Gellis, Betsy M. Ferguson, Jack L. Strominger, Jonathan Zonana, Narayanaswamy Ramesh, Zuhair K. Ballas, and Raif S. Geha Jordan…